PUBLICATIONS
Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence.
Carapeto P, Iwasaki K, Hela F, Kahng J, Alves-Wagner AB, Middelbeek RJW, Hirshman MF, Rutter GA, Goodyear LJ, Aguayo-Mazzucato C; Nat Metab; 2024.
SenNet recommendations for detecting senescent cells in different tissues.
Suryadevara V, Hudgins AD, Rajesh A, Pappalardo A, Karpova A, Dey AK, Hertzel A, Agudelo A, Rocha A, Soygur B, Schilling B, Carver CM, Aguayo-Mazzucato C, Baker DJ, Bernlohr DA, Jurk D, Mangarova DB, Quardokus EM, Enninga EAL, Schmidt EL, Chen F, Duncan FE, Cambuli F, Kaur G, Kuchel GA, Lee G, Daldrup-Link HE, Martini H, Phatnani H, Al-Naggar IM, Rahman I, Nie J, Passos JF, Silverstein JC, Campisi J, Wang J, Iwasaki K, Barbosa K, Metis K, Nernekli K, Niedernhofer LJ, Ding L, Wang L, Adams LC, Ruiyang L, Doolittle ML, Teneche MG, Schafer MJ, Xu M, Hajipour M, Boroumand M, Basisty N, Sloan N, Slavov N, Kuksenko O, Robson P, Gomez PT, Vasilikos P, Adams PD, Carapeto P, Zhu Q, Ramasamy R, Perez-Lorenzo R, Fan R, Dong R, Montgomery RR, Shaikh S, Vickovic S, Yin S, Kang S, Suvakov S, Khosla S, Garovic VD, Menon V, Xu Y, Song Y, Suh Y, Dou Z, Neretti N; Nat Rev Mol Cell Biol; 2024.
Heterogeneity of increased biological age in type 2 diabetes correlates with differential tissue DNA methylation, biological variables, and pharmacological treatments.
Cortez BN, Pan H, Hinthorn S, Sun H, Neretti N, Gloyn AL, Aguayo-Mazzucato C; Geroscience; 2024.
Interaction between Autophagy and Senescence in Pancreatic Beta Cells.
Hela F, Aguayo-Mazzucato C; Biology (Basel). 2023
Pancreatic β-cell senescence in diabetes: mechanisms, markers and therapies.
Cha J, Aguayo-Mazzucato C, Thompson PJ; Front Endocrinol (Lausanne). 2023.
Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells.
Iwasaki K, Lalani B, Kahng J, Carapeto P, Sanjines S, Hela F, Abarca C, Tsuji T, Darcy J, Bartke A, Tseng YH, Kulkarni RN, Aguayo-Mazzucato C. Front Endocrinol (Lausanne). 2023
Regulation of Cellular Senescence in Type 2 Diabetes: From Mechanisms to Clinical Applications.
Iwasaki K, Abarca C, Aguayo-Mazzucato C; Diabetes and Metabolism Journal; 2023
“FunDNAmethyl” mechanism for developmental restriction of a beta-cell subpopulation".
Aguayo-Mazzucato C., Stitzel LM; Diabetes; 2023.
Clearance of p16Ink4a-positive cells in a mouse transgenic model does not change β-cell mass and has limited effects on their proliferative capacity.
Bahour N, Bleichmar L, Abarca C, Wilmann E, Sanjines S, Aguayo-Mazzucato C; Aging (Albany NY); 2023
PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53
Rubin de Celis MF, Garcia-Martin R, Syed I, Lee J, Aguayo-Mazzucato C, Bonner-Weir S, Kahn BB; Proc Natl Acad Sci U S A; 2022
Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype
Kuehnemann C, Hu KQ, Butera K, Patel SK, Bons J, Schilling B, Aguayo-Mazzucato C, Wiley CD. Front Endocrinol (Lausanne). 2022
Biological age in diabetes and precision medicine.
Cortez BN, Bahour N, Aguayo-Mazzucato C. Aging (Albany NY); 2022
NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.
SenNet Consortium; Nature Aging; 2022.
Bromodomain Inhibition Reveals FGF15/19 as a Target of Epigenetic Regulation and Metabolic Control
Kozuka C, Efthymiou V, Sales VM, Zhou L, Osataphan S, Yuchi Y, Chimene-Weiss J, Mulla C, Isganaitis E, Desmond J, Sanechika S, Kusuyama J, Goodyear L, Shi X, Gerszten RE, Aguayo-Mazzucato C, Carapeto P, Teixeira SD, Sandoval D, Alonso-Curbelo D, Wu L, Qi J, Patti ME; Diabetes; 2022 Jan 31
Diabetes mellitus correlates with increased biological age as indicated by clinical biomarkers
Nadine Bahour, Briana Cortez, Hui Pan, Hetal Shah, Alessandro Doria, Cristina Aguayo-Mazzucato; GeroScience; 2021
Effects of exercise on cellular and tissue aging
Priscila Carapeto, Cristina Aguayo-Mazzucato; Aging (Albany NY); 2021
Unique beta-cell senescence-associated secretory phenotype (SASP) from physiological and chemically induced models
Ayush Midha, Hui Pan, Cristian Abarca, Joshua Andle, Priscila Carapeto, Susan Bonner-Weir, Cristina Aguayo-Mazzucato; Diabetes; 2021
Functional changes in beta-cells during ageing and senescence
Cristina Aguayo-Mazzucato; Diabetologia; 2020
β-cell senescence in type 2 diabetes
Cristina Aguayo-Mazzucato and Ayush Midha; Aging (Albany NY); 2019
Acceleration of β-cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes
Cristina Aguayo-Mazzucato, Joshua Andle, Terrence B. Lee, Jr., Jan van Deursen, Gordon Weir, Susan Bonner-Weir; Cell Metabolism; 2019
Pancreatic β-cell regeneration as a possible therapy for diabetes
Cristina Aguayo-Mazzucato and Susan Bonner-Weir; Cell Metabolism; 2018
Understanding the growing epidemic of type 2 diabetes in the Hispanic population living in the United States
Cristina Aguayo‐Mazzucato, Paula Diaque, Aleksandar Kostic, Augusto Enrique Caballero; Diabetes Metabolism Research and Reviews; 2019
T 3 Induces Both Markers of Maturation and Aging in Pancreatic b-Cells
Cristina Aguayo-Mazzucato, Terence B. Lee Jr., Michelle Matzko, Amanda DiIenno, Habib Rezanejad, Preeti Ramadoss, Thomas Scanlan, Ann Marie Zavacki, P. Reed Larsen, Anthony Hollenberg, Clark Colton, Arun Sharma and Susan Bonner-Weir; Diabetes; 2018
β-cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance
Cristina Aguayo-Mazzucato, Mark van Haaren, Magdalena Mruk, Jan Van Deursen, Gordon C. Weir, Susan Bonner-Weir; Cell Metabolism 2017
Pancreatic β-cell heterogeneity revisited
Cristina Aguayo-Mazzucato and Susan Bonner-Weir; Nature; 2016
Dynamic development of the pancreas from birth to adulthood
Susan Bonner-Weir, Cristina Aguayo-Mazzucato & Gordon C. Weir; Ups J Med Sci; 2016
MAFA and T 3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC
Cristina Aguayo-Mazzucato, Amanda DiIenno, Jennifer Hollister-Lock, Christopher Cahill, Arun Sharma, Gordon Weir, Clark Colton, and Susan Bonner-Weir; JCEM; 2015
β-cell dedifferentiation in diabetes is important, but what is it?
Gordon C Weir, Cristina Aguayo-Mazzucato & Susan Bonner-Weir; Islets; 2013
Genetic Disruption of SOD1 Gene Causes Glucose Intolerance and Impairs b-Cell Function
Giovanna Muscogiuri, Adam B. Salmon, Cristina Aguayo-Mazzucato, Mengyao Li, Bogdan Balas, Rodolfo Guardado-Mendoza, Andrea Giaccari, Robert L. Reddick, Sara M. Reyna, Gordon Weir, Ralph A. DeFronzo, Holly Van Remmen, and Nicolas Musi; Diabetes; 2013
PDX1 in Ducts Is Not Required for Postnatal Formation of b-Cells but Is Necessary for Their Subsequent Maturation
Lili Guo, Akari Inada, Cristina Aguayo-Mazzucato, Jennifer Hollister-Lock, Yoshio Fujitani, Gordon C. Weir, Christopher V.E. Wright, Arun Sharma and Susan Bonner-Weir; Diabetes; 2013
Thyroid Hormone Promotes Postnatal Rat Pancreatic b-Cell Development and Glucose-Responsive Insulin Secretion Through MAFA
Cristina Aguayo-Mazzucato, Ann Marie Zavacki, Alejandra Marinelarena, Jennifer Hollister-Lock, Ilham El Khattabi, Alessandro Marsili, Gordon C. Weir, Arun Sharma, P. Reed Larsen and Susan Bonner-Weir; Diabetes; 2013
Subpopulations of GFP-Marked Mouse Pancreatic Cells Differ in Size, Granularity, and Insulin Secretion
Hitoshi Katsuta, Cristina Aguayo-Mazzucato, Rimiko Katsuta, Tomoyuki Akashi, Jennifer Hollister-Lock, Arun J. Sharma, Susan Bonner-Weir, and Gordon C. Weir; Endocrinology; 2012
Mice with a Targeted Deletion of the Type 2 Deiodinase Are Insulin Resistant and Susceptible to Diet Induced Obesity
Alessandro Marsili , Cristina Aguayo-Mazzucato , Ting Chen , Aditi Kumar, Mirra Chung, Elaine P. Lunsford, John W. Harney, Thuy Van-Tran, Elena Gianetti, Waile Ramadan , Cyril Chou, Susan Bonner-Weir , Philip Reed Larsen , Jorge Enrique Silva , Ann Marie Zavacki; PLoS One; 2011
Tissue-specific disallowance of housekeeping genes: The other face of cell differentiation
Lieven Thorrez, Ilaria Laudadio, Katrijn Van Deun, Roel Quintens, Nico Hendrickx, Mikaela Granvik, Katleen Lemaire, Anica Schraenen, Leentje Van Lommel, Stefan Lehnert, Cristina Aguayo-Mazzucato, Rui Cheng-Xue, Patrick Gilon, Iven Van Mechelen, Susan Bonner-Weir, Frédéric Lemaigre and Frans Schuit; Genome Res; 2011
Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells
A. Jermendy, E. Toschi, T. Aye & A. Koh, C. Aguayo-Mazzucato, A. Sharma, G. C. Weir, D. Sgroi and S. Bonner-Weir; Diabetologia; 2011
Stem cell therapy for type 1 diabetes mellitus
Cristina Aguayo-Mazzucato and Susan Bonner-Weir; Nat Rev Endocrinol; 2010
Restructuring of Pancreatic Islets and Insulin Secretion in a Postnatal Critical Window
Cristina Aguayo-Mazzucato , Carmen Sanchez-Soto, Victoria Godinez-Puig, Gabriel Gutiérrez-Ospina, Marcia Hiriart; PLoS One; 2006